Mediterranean Chicken Casserole
This Mediterranean Chicken Casserole is packed with the flavors of spinach, tomatoes, oregano, and feta cheese. Baking it on top of a bed of cauliflower rice makes it a complete family meal in one dish. Loaded with juicy chicken, this simple comfort food really is a complete meal. Perfect for a weeknight dinner that literally takes minimal effort to make. This easy one-pot meal seriously has the best flavor!
One of my favorite types of food is Greek. I am 25% Greek and love that part of my heritage. My maternal grandfather was Greek and made delicious food. He worked as a chef for years, owned a pizzeria, and then worked again in the food industry later in life before retiring.
Growing up there was always lamb, roasted potatoes, and lots and lots of feta cheese. The saltiness of the feta adds so much flavor to any dish it is in.
I chose to use feta in this casserole to give it a Mediterranean flair. It is lighter than some of my other casseroles with the addition of spinach and by baking it on a bed of cauliflower rice.
I decided to layer this on top of cauliflower rice to force my children to eat an extra vegetable. Half kidding. I really just had a bag of steamable cauliflower crumbles from Costco I needed to use. I love having dinner bake in one dish so adding the cauliflower rice was a great way to squeeze in another veggie and bulk up this dish.
Be sure to try my Keto Turkey Casserole and this Keto Zucchini Casserole for other easy weeknight meals.
Ingredients
- Cream cheese – This needs to be softened before using.
- Greek yogurt – Make sure that it is plain – not flavored!
- Mayonnaise – Adds richness and a creamy texture.
- Parsley – For flavor.
- Oregano – For flavor.
- Minced garlic – For flavor.
- Salt – You can add more or less per your personal preference.
- Crumbled feta cheese – This will be used in a couple of areas of this recipe.
- Cooked chicken – You’ll need about 1.5 pounds. I cube it because I prefer this texture.
- Fresh spinach – A great way to add veggies to the daily diet.
- Tomato – Chop it up before adding.
- Green onion – Slice thinly.
- Cauliflower rice – This is optional but makes a great low-carb base.
See recipe card for quantities.
How to Make Mediterranean Chicken Casserole
Preheat the oven to 350 degrees.
Step One: If you are going to use the cauliflower base, mix the cauliflower rice with the salt and garlic. Spread that cooked mixture into the bottom of a 9X13 casserole dish.
Step Two: Mix the first seven ingredients well. Fold in 1/2 cup of the feta cheese, then the chicken, tomato, spinach, and green onion. Spread that mixture on top of the rice layer or directly into the bottom of the baking dish if you’re not adding a rice layer. Put the rest of the feta cheese on top.
Step Three: Bake in the oven for 30-35 minutes. It will be hot with the cheese beginning to brown.
Top Tip💡
This easy dinner recipe is also a great way to use leftover chicken or pre-cooked chicken. You can even buy a rotisserie chicken and use some of the meat from that in this Greek chicken casserole dish.
Variations
- Tomatoes – If you don’t want to chop up the tomato, you can also add halved grape or cherry tomatoes.
- Olives – Add a pop of flavor by mixing in seedless olives. You can dice up green olives, kalamata olives, black olives, or any type that you like.
- Change flavors – Mincing some fresh garlic cloves and adding some artichoke hearts are an easy way to change the flavor. You can also add sliced red onion, and more fresh herbs. If you don’t want to add feta cheese to the top, you can top it with parmesan cheese or tangy feta cheese.
- Chicken – Cubed chicken is how I love to add meat, but you could also shred skinless chicken breasts or even add ground chicken as the chicken of your choice. This delicious casserole is forgiving in options.
See this Keto Chicken Mushroom Casserole for another one of my favorites.
Equipment
To make this delicious chicken casserole, you’ll want to have a small bowl or a large bowl for mixing, measuring cups, and a casserole dish. I also use a cast iron skillet to cook my chicken.
Storage
Once you make this Mediterranean Chicken Bake, you’ll likely have some leftovers. Be sure to let the Mediterranean chicken recipe cool down all the way, then store leftovers in an airtight container. Keep the leftovers in the fridge, and eat within 2-3 days. Reheat thoroughly before eating.
While freezing this recipe is technically possible, I really recommend making and eating fresh. This ensures that all the flavors are full of depth!
Common Questions
Absolutely! I do this all the time, and my whole family is so happy that we have a hearty meal ready to enjoy. It’s a great option to have ready and waiting on those days of long work hours, sports, and after-school activities.
This is where you can alter the added cheeses and put in other fresh veggies. Diced bell peppers and even some chunks of sweet potatoes can quickly change the flavor into something new and delicious. Pair it with some crusty bread, and you have a whole new meal!
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Mediterranean Chicken Casserole
Ingredients
Cauliflower Base (optional):
- 16 oz cooked cauliflower rice or finely chopped cauliflower
- 1/2 tsp salt
- 1 tsp minced garlic
Instructions
- Preheat oven to 350.
- If using the cauliflower base mix together the steamed cauliflower rice with the salt and garlic. Spread in the bottom of a 9 x 13 baking dish.
- Combine the first 7 ingredients and mix well. Fold in 1/2 cup of the feta cheese, the chicken, spinach, tomato, and green onion. Spread on top of the prepared cauliflower rice or in the bottom of a 9 x 13 baking dish.
- Sprinkle the remaining 1/2 cup feta cheese on top. Bake for 30-35 minutes until hot.
Nutrition
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Originally Published February 15, 2018. Revised and Republished April 10, 2025.
Hi. Looks fantastic and cant wait to try . Is there something I can use on replace of the cream cheese?
Ricotta cheese or mascarpone would be best. Sour cream might work too.
This is delicious I added a couple grape leaves and found lemon garlic riced cauliflower. I love it! Thank you!
Goodness this is so tastey. I made it last night. Hubby approved. Thank you for such amaizing recipes.
I think I’m going to nix the cauliflower base and have it cold like chicken salad on 1/2 a joseph’s flatbread for an S lunch (:
Yes! I like it cold too.
This looks fantastic! I was born in Athens while my dad was in the US Navy stationed there. We picked up so many food traditions there. Now my kids love it too! Can’t wait to try this.
Yummy and just yummy. Loved this! Thanks f😘
FYI…. the recipe doesn’t have the green onions /chives listed , although you mention it in the blog posts.
Thank you! I noticed that myself but forgot to fix it.
This looks wonderful!! Thank you for all your wonderful recipes.
I will be making this tonight. Can leftovers be frozen?
I’m not sure freezing this would work because the spinach and tomatoes may release too much liquid. You could probably freeze the chicken in the sauce and then thaw and add the fresh veggies right before baking.