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5 from 4 votes

Stuffed Meatloaf with Cheese

Ooey gooey cheese stuffed meatloaf is what your taste buds dream about at night. Every bite is filled with an explosion of Italian flavors, cheese, and pepperoni. How could the combination of pizza and meatloaf not be delectable?
Prep Time10 mins
Cook Time40 mins
Total Time50 mins
Course: Main Course
Cuisine: American, Italian, Italian American
Servings: 10
Calories: 345kcal
Author: Taryn


  • 2.5 - 3 lb ground turkey
  • 2 eggs
  • 1 tbsp each: dried garlic powder onion powder, minced garlic, minced onion
  • 2 tsp each: dried basil parsley, oregano, salt
  • 16 oz mozzarella cheese cut in half lengthwise to make two approx. 2 x 2 x 6 in pieces
  • 5 oz pepperoni slices
  • pasta sauce to serve


  • Preheat oven to 350.
  • Combine the ground turkey with the eggs and spices. Put 1/3 of it on a baking pan and make an 7 x 10 inch rectangle. Put a layer of pepperoni in the middle. Put the mozzarella on top of the pepperoni. Cover the sides and top of the mozzarella with more pepperoni. Use the rest of the ground turkey to encase the cheese and pepperoni. Put the remaining pepperoni on the outside of the meatloaf.
  • Bake for 40-50 minutes or until the meat is 160 on a meat thermometer.


Calories: 345kcal | Carbohydrates: 2g | Protein: 41g | Fat: 19g | Saturated Fat: 8g | Cholesterol: 145mg | Sodium: 604mg | Potassium: 420mg | Sugar: 0g | Vitamin A: 385IU | Vitamin C: 0.1mg | Calcium: 241mg | Iron: 1.5mg